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According to the report “Global 3D Printed Materials Market Analysis and Forecast (2016-2022)” published recently by ResearchandMarkets, the global 3D printing materials market will reach US$1.52 billion by 2022, and the dental and medical industries will become important. Assist force.

And just recently, the combination of 3D printing and the medical field has gone one step further.

The Department of Urology of the South Hospital of Renji Hospital, Shanghai Jiao Tong University School of Medicine, took over the headlines of the medical profession last week. It successfully applied 3D printing technology to treat urinary diseases for the first time in the world.

In the case of the world’s first 3D printed urinary disease, the operation was originally a sacral nerve stimulator implantation, which is a new minimally invasive treatment that is implanted in the buttocks with a small programmable device. The symptoms of patients with incontinence are treated by remote external devices. The device includes a pulse generator, an electrode, and a lead for connecting both, which has been widely used clinically.

According to Lei Feng network (search "Lei Feng network" public concern) to the relevant doctors understand that these types of surgery is a minimally invasive technique, has made great progress than the more traditional technology, but there are still some problems. "Because people's fistulas are very narrow, implanting electrodes with intraoperative punctures is not only extremely difficult, it takes hours, and doctors and patients may also have radiation risks."

According to Lu Jianwei, deputy chief physician of urology, the 3D printing technology used in this surgery can accurately simulate real objects and fully understand the anatomical features of the patient's radial nerves and fistulas, making it easier for doctors to design implantable solutions. This technology only needs to be punctured and implanted at the reserved point of the customized 3D model and electrodes, and the duration can be shortened to within 5 minutes.

This is undoubtedly a solid step for precision medicine. According to the official website, the hospital is currently applying for national patents for this technology. "With the requirements of precision medicine and rapid rehabilitation medicine, 3D printing technology will become more and more widely used and become one of the hot spots in the medical field," said Xue Weiru, director of urology.

Three possibilities for medical and 3D printing

In fact, 3D printing was born as early as the 90s of the last century, and in recent years, the popularity of customer culture has attracted the attention of the industry. The application of 3D printing is very extensive. From the industrial level to the consumer level, looking around the current market, its combination with medical care is “from shallow to deep, from easy to difficult,” and includes the following three aspects.

The first is the external device. This is also the initial application of 3D printing in the medical field. It is mainly played as an "assistive" role. Such as 3D models, rehabilitation aids, etc.

Such applications are relatively difficult to implement and universal, and e-NABLE, a non-profit organization, provides disabled children with prosthetic limbs at a low price. The cost is only around US$100. Another example is that Xiangya Hospital of Central South University successfully used 3D technology to assist surgeons in surgery last year. However, this process was only performed before the preoperative 3D visualization technology modeling, and the use of 3D printing model for surgical planning, in fact, still belongs to the auxiliary surgery. One means is in the early stages of 3D printing.

Followed by implants, the most common applications should be dentistry and orthopedics, but they are now beginning to be applied to the human body.

According to Lei Feng network, Renji Nanyuan Hospital actually used 3D printing to successfully perform left atrial appendage closure surgery last year. This procedure is also a minimally invasive procedure to reduce the risk of long-term disability or death from thromboembolism in patients with atrial fibrillation. At present, the clinically validated and successfully introduced domestic hospital treatment program is the WATCHMAN occluder, but the shape of the left atrial appendage varies from person to person, and the form of the patient's left atrial appendage needs to be well understood at the time of implantation. During this operation, the doctor used the 3D printer to create an occluder model of the left atrial appendage through a fine-scanning image of the patient's left atrial appendage and developed a personalized surgical plan.

The third stage of 3D printing in medical applications is bioprinting, which uses body tissue solutions and uses inkjet technology to directly print organs such as blood vessels, nerves, and skin. This bioengineering application is in the research and development stage and has not really been used in the clinical field.

In addition, there are some researches using 3D bioprinting technology to assist doctors in evaluating the efficacy of new drugs. The printed tissue can monitor drug interactions in different organs in real time to accelerate the speed of iterations.

Three major difficulties in promotion

Although Yan Chai Hospital successfully implemented the 3D printing operation last year, it has not received large-scale promotion after more than a year. According to Chen Lianghong, the 3D printer vendor FormLab CEO, 3D printing is used successfully in hospitals and there are three difficulties.

The first is that the equipment technology is not yet mature, 3D printing equipment must obtain the qualifications of the imported hospital, one should guarantee the accuracy of the product, and the second one needs to undergo a tedious review process.

The medical field can't tolerate any errors, and the current maturity of 3D printing technology is not perfect, and the 3D printing manufacturers with fine-scale operation levels can rarely be found. The process of applying through ISO is as short as one year and as many as several years. The cumbersome policy review process undoubtedly causes the lag in the popularization and application of technology.

Take Dental Lab's Dental SG resin as an example. In order to prevent the product from generating repetitiveness, 3D printing materials must pass ISO quality system certification to ensure the biocompatibility of the product before use. Dental materials are still the case, not to mention implanting 3D printed materials in the body.

Followed by the doctor's education and training system needs to be improved. “At present, there are few surgical trainings for 3D printing. To get a large-scale spread and application, the professional teaching of doctors is indispensable. Now the hospital's 3D printing technology is still in an early stage of exploration.”

Of course, ginger is still hot, but experienced doctors have formed their own surgical habits. It is relatively difficult for them to accept related 3D printing technologies, and young people who are relatively more challenging and innovative are not yet available. The ability to try the main knife has also made it difficult to promote 3D printing-related technologies.

The reason behind this is that the current 3D printing manufacturers have not yet formed a linkage with the hospitals to standardize the surgical operation standard processes and develop training content. The development of the 3D printing surgical program only stopped at the single-chamber “fight alone” and failed to form a virtuous circle.

The third problem lies in the need to realize commercialization in the medical field. The closed loop of 3D printing has not yet been formed. To introduce medical 3D printers will also bring a lot of money. Whether the hospital has an open mind and is willing to try, it also has to face the test of funds and the baptism of ideas. In addition, traditional conservative therapies are already mature for patients. Because of the customization features, the new type of surgery has high costs and high fees, which also hinders its promotion. How to link doctors, patients, and providers of 3D printing solutions in a way that all three parties can open up and accept is an important issue that hospitals need to face in the future.

A related report issued by SmarTech Markets pointed out that the medical market will account for nearly 37% of 3D printing industry, but there is still resistance in industry awareness, raw material costs, material compatibility and industry support, making medical applications currently available for 3D printing. It's just some fresh news from the newspapers. If the successful case of Yan Chai Hospital no longer becomes the headline of the medical profession, 3D printing will become the universal treatment method in the medical field.

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